Disulfonated tetraphenyl chlorin (TPCS2a)–induced photochemical internalisation of bleomycin in patients with solid malignancies: A first-in- man phase I dose escalation clinical trial
نویسندگان
چکیده
1 Academic Unit of Oral and Maxillofacial Surgery, UCL Eastman Dental Institute, London, UK 2 UCL Department of Surgery, London, UK 3 Department of Radiation Biology, Oslo University Hospital, Oslo, Norway 4 PCI Biotech AS, Lysaker, Norway 5 Cancer Clinical Trials Unit, University College London Hospitals, London, UK 6 Head and Neck Unit, University College London Hospitals, London, UK 7 UCL Cancer Institute, London, UK
منابع مشابه
Photochemical internalization of bleomycin and temozolomide--in vitro studies on the glioma cell line F98.
Here we evaluate the photosensitizer meso-tetraphenyl chlorin disulphonate (TPCS2a) in survival studies of rat glioma cancer cells in combination with the novel photochemical internalization (PCI) technique. The tested anticancer drugs were bleomycin (BLM) and temozolomide (TMZ). Glioma cells were incubated with TPCS2a (0.2 μg ml(-1), 18 h, 37 °C) before BLM or TMZ stimulation (4 h) prior to re...
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